NAFTIN® Cream 2% (naftifine HCl 1%) New Pregnancy B
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How Supplied:

NAFTIN® (naftifine hydrochloride) Cream 2% is a white to off-white cream supplied in a collapsible tube in the following size: 45g.

Active Ingredients:

naftifine hydrochloride

Indications and Usage:

NAFTIN® (naftifine hydrochloride) Cream 2% is an allylamine antifungal indicated for the treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by the organism Trichophyton rubrum in adult patients ≥18 years of age.

Prescribing Instructions:

Prescribing Information Instructions [PDF]

Side Effects and Contraindications:

The most common adverse reaction (≥1%) is pruritus.


Merz Pharmaceuticals LLC

Clinical Pearls & Key Features:

  • NAFTIN® Cream 2% provides clinically significant efficacy in interdigital tinea pedis and tinea cruris.
  • NAFTIN® Cream 2% offers patients a clinically effective option with short treatment duration
  • NAFTIN® Cream 2% is available in a tube size that is ideal for 2-week treatment.
  • Results with NAFTIN® Cream 2% continue to improve 2-4 weeks after treatment.1,2


"NAFTIN® Cream 2% provides patients with the convenience of a shorter treatment course of 2 weeks because naftifine continues to kill the most common dermatophyte after cessation of treatment. Studies have shown that patient adherence to long-term regimens in all skin diseases is very limited, and this novel formulation allows clinical success in scenarios that mirror real use."

Alan B. Fleischer, Jr., MD
Professor of Dermatology
Wake Forest University School of Medicine Medical Center,
Winston-Salem, NC;
Executive Director of Dermatology
Merz Pharmaceuticals LLC


1. Parish LC, Parish JL, Routh HB, et al. A randomized, double-blind, vehicle-controlled efficacy and safety study of naftifine 2% cream in the treatment of tinea pedis. J Drugs Dermatol. 2011;10(11):1282-1288.
2. Parish LC, Parish JL, Routh HB, et al. A double-blind, randomized, vehicle-controlled study evaluating the efficacy and safety of naftifine 2% cream in tinea cruris. J Drugs Dermatol. 2011;10(10):1142-1147.